If the headaches continue, let your doctor know Less common side-effects What can I do if I experience this? Tummy abdominal bloating or discomfort Taking the tablets with food helps to reduce these side-effects. If they continue or become troublesome, speak with your doctor Allergic skin reactions such as itching and rash Use a moisturiser to soothe your skin.
If the rash continues or is severe, contact your doctor for advice. If you have any questions about this medicine ask your pharmacist. Are you protected against flu?
Further reading and references. Join the discussion on the forums. Health Tools Feeling unwell? Assess your symptoms online with our free symptom checker. Start symptom checker. Common betahistine side-effects these affect less than 1 in 10 people. Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. Betahistine may be associated with weight loss. The reason is that centrally acting antihistamines seem to cause weight gain Hampton, , and by the same token, histamine agonists may cause weight loss.
According to a study of Barak, weight loss averaging 4. Barak et al, A later trial of weight gain in patients on olanzapine, documented rather small differences Barak et al, According to Vlastarakos et al. While we agree that it is prudent to avoid use of drugs lacking rigorous data in pregnancy, the advice in this case does not appear to be supported by any adverse event data. Betahistine may help arthritis. According to Tang et al , Betahistine suppressed inflammation in mice with arthritis.
We have not noticed any effect of betahistine in our patients on arthritis. Little has been published about betahistine being incompatible with anything. If one believes in the histamine agonism mechanism, it would make little sense to take a centrally acting antihistamine medication with betahistine as the betahistine might not work.
This covers a lot of ground including many conventional "dizziness" drugs. Still, if there is a balance between these drugs, one might nevertheless end up better with respect to vertigo. A person on betahistine should be able to take purely "peripheral" acting antihistamines such as Claratin, Allegra and Zyrtec. Similarly a person on betahistine should not take antidepressants with central antihistamine side effects such as the "tryptylines".
This includes Elavil and Pamelor. Practically, we have not noted any interaction problems. According to Strupp , Betahistine is metabolized rapidly, and this can be blocked with an MAO inhibitor. He reported using a very large but still smaller amounts of betahistine than he favors, when it was combined with 2.
In our opinion, this is a large dose, with or without selegiline. The lack of a placebo makes this uncontrolled study potentially subject to bias. Selegiline itself is not thought to be especially dangerous, and it does seem reasonable to contemplate the combination of the two medications, especially for situations where the situation is difficult e.
As of we have not tried this. Serc betahistine Timothy C. Tinnitus is not helped by Betahistine Wegner et al, Our clinical judgement is that betahistine does have positive effects on vertigo, but that it is very hard to determine how great these effects are due to the immense number of poor studies and biased reviews concerning betahistine's efficacy.
Availability and ordering At the time of this update , we generally just put the order into a mail-order compounding pharmacy. For our "Epic" EMR, this is the way the order looks: While there are some oddities to this order template, as one does not really dispense "60 g", this seems to work reasonably well, and the pharmacists understand that 60 means 60 capsules, not 60 grams.
CNS Receptor Location Action H1 postsynaptic excitatory vestibular H2 postsynaptic excitatory vestibular H3 presynaptic autoreceptor reduces histamine H4 outside CNS Inhibitory vestibular Although betahistine does not closely resemble histamine see above , in the body it is a histamine agonist.
All four types of histamine receptors are found in the mouse ear as well Takumida et al, Betahistine is a potent H3 receptor antagonist.
Fujino et al reported betahistine to have a positive effect when combined with rehabilitation. Guneri et al reported that betahistine improved outcome for patients treated for BPPV with the Epley maneuver. This randomized double-blind study had roughly 25 patients in each arm. The effect size was not large. Mukhopadhyay et al suggested betahistine was a "magic bullet" for PONV after middle ear surgery, using a prospective double-blind placebo controlled design.
This is reasonable evidence for a positive effect of betahistine. Albu et al , from Romania, recently reported that high-dose betahistine i. This was randomized and double-blind. There was no statistical difference between the two groups in vertigo control. This doesn't say much for IT dexamethasone no surprise there. While we are uncertain about the validity of this result, we do typically "double up" on betahistine when there is a Meniere's flare.
Note also the later study from Albu in below, where it suggests that IT steroids and betahistine are better together than alone. Soklova et al compared betahistine to Ginkgo biloba extract, and reported similar effectiveness.
As Ginkgo may be a placebo, this is not strong evidence for Betahistine. This was an "open label" observational trial of vestibular vertigo. As it is open label, the quality of evidence is not as strong as placebo controlled trials. Ramos et al , in a meta-analysis, suggested that betahistine was "an effective and safe option for the treatment of peripheral vertigo".
Ramos was thus reviewing work of others. This would argue that betahistine is ineffective for Meniere's disease. There were however some secondary measures such as attacks of rotatory or positional vertigo that improved slightly in the high-dose group. This would support the conjecture that betahistine is a placebo. Albu et al , from Romania, reported much better responses from betahistine plus IT steroids, than IT steroids alone.
They used high-dose 48 mg TID. Opposite to the German study above which used similar dosing, this would argue in favor of betahistine. Yilmaz, H. They reported "simultaneous administration of betahistine during noise had no protective effect on permanent increase in the threshold". So no effect. Parfenov, V. We think this dose is a little low. Seyed Tootoonchi, S.
Side Effects Side-effects are generally minimal. In its favor, betahistine does not cause drowsiness and has no effect on driving, reaction time or visual acuity Betts et al, Aksoy et al reported that in rats, betahistine exacerbates amikacin ototoxicity. Other effects not necessarily bad Betahistine may be associated with weight loss. References: Adrion, C. Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial BEMED trial.
BMJ, , h Betahistine Exacerbates Amikacin Ototoxicity. However, do not drive if you feel dizzy or if you feel an attack of vertigo coming on. It's likely that you will have to stop driving until your symptoms are under control. There's no firm evidence to suggest that taking betahistine will reduce fertility in either men or women. However, speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Betahistine does not affect any type of contraception, including the combined pill and emergency contraception.
Page last reviewed: 29 August Next review due: 29 August Betahistine On this page About betahistine Key facts Who can and can't take betahistine How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions. Symptoms include: dizziness vertigo ringing in the ears tinnitus loss of hearing feeling sick nausea The full name of this medicine is betahistine dihydrochloride.
It comes as tablets and is available on prescription only. Help us improve our website Can you answer a quick question about your visit today? Betahistine is suitable for adults only. You'll usually take your tablets 3 times a day, leaving 6 to 8 hours between doses. Common side effects include headache, feeling sick or indigestion. It's best to take your tablets with or after food. This way it's less likely to upset your stomach.
Betahistine is also known by the brand name Serc. Tell your doctor or pharmacist if you have: had an allergic reaction to betahistine or any other medicines in the past high blood pressure due to an adrenal tumour ever had a stomach ulcer sometimes called peptic ulcer asthma. Betahistine comes as 8mg or 16mg tablets.
How much to take The usual starting dose is 16mg, taken 3 times a day. Leave 6 to 8 hours between doses. What if I take too much? Urgent advice: Contact for advice now if:. What if I forget my medicine?
Common side effects These common side effects happen in more than 1 in people. Talk to your pharmacist or doctor if the side effects bother you or do not go away: feeling sick nausea indigestion acid reflux bloating or mild stomach ache headache Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to betahistine. Information: You can report any suspected side effect to the UK safety scheme.
What to do about: feeling sick - take betahistine with or after a meal or snack. It may also help if you do not eat rich or spicy food. Many medications can cause side effects.
A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Stop taking the medication and seek immediate medical attention if any of the following occur:. Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should use this medication. Asthma: This medication may make the symptoms of breathing problems worse. If you have asthma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects.
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